PIOGLITAZONE a diabetic drug called Pioglitazone (Actos®) may help decrease blood pressure in polycystic kidney disease. Preliminary work in the laboratory with the PKD model has revealed Pioglitazone (Actos®) improves both liver and kidney cysts. Clinical trials will begin to see if Actos® does decrease cyst formation in humans. So far it does so in the PKD model. Wait for trial to complete.